Smart Weigh e ikemiselitse ho thusa bareki ho eketsa tlhahiso ka theko e tlase.
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Smart Weigh e ikemiselitse ho thusa bareki ho eketsa tlhahiso ka theko e tlase.
Mongoli: Smartweigh–Multihead Weighter
Likhetho tse 'ne tsa liphutheloana tsa aseptic tse lokelang ho nahanoa. Kajeno, mahlale a fapaneng a shebaneng le baetsi ba meriana le biopharmaceutical ke: (1) likamore tse hloekileng tsa sehlopha sa 100, (2) li-isolators, (3) lits'ebetso tse thibelang phihlello (RABS), (4) litsamaiso tsa tšebeliso e le 'ngoe. Ke efe e molemo ho uena? 1. Kamore ea Bohloeki ea Sehlopha sa 100: Theknoloji ea kamore ea bohloeki e qalile ka bo-1960 hore e sebelisoe indastering ea lifofane le tsa elektroniki ho qoba tšilafalo ea likaroloana tse nyane.
Libaktheria ke likaroloana, 'me indasteri ea meriana kapele e ile ea hlokomela hore tsebo ena e ka tiisa moea o hloekisitsoeng. aleksandarlittlewolf - www.freepik.comPharma-gowning-young-technologist-putting-protective-rubber-gloves-production-factory-freepik-web.jpg Likamore tse hloekileng tsa Sehlopha sa 100 ke tsona tse atileng haholo tlhahisong ea aseptic (ISO 5 le A/B Class performance e lekana), ka ho sebelisa sefe ea matla a phahameng a particulate air (HEPA) ho tlosa likaroloana tsohle le libaktheria. Laminar ea molumo o moholo kapa phallo ea moea unidirectional e fokotsa ho fetisoa ha likaroloana ho tloha sebakeng se seng ho ea ho se seng.
Lilemong tsa bo-1970, ho tlatsoa ha aseptic ho ne ho etsoa ka mechini e ikhethang e tlas'a liphanele tsa filthara ea HEPA. Likarolo tsa mochini tse kaholimo ho sets'oants'o ke mohloli o ka bang teng oa tšilafalo, 'me ha nako e ntse e ea li tsamaisoa ka hohle kamoo ho ka khonehang ka tlase ho boemo ba ho sebetsa. Ho tsepamisa mohopolo hamolemo ho moea o tlhotliloeng mochining, likoahelo tsa lifensetere tsa polasetiki le tsona li kentsoe.
Lesela la fensetere le boetse le hopotsa motho ea sebetsang ho qoba ho ama mochine kapa sehlahisoa. Bahlahisi ba retelehetse ho 100% ea siling ea HEPA ho laola likamore tsohle ho ea sehlopheng sa 100. Sena se ntlafatsa taolo, empa se eketsa litšenyehelo tsa lichelete le tsa ts'ebetso, haholo-holo tsamaiso ea ho sebetsana le moea.
2. Opto-Isolators: Lilemong tsa bo-80 le 90, li-isolators li ile tsa ntlafatsoa ho ntlafatsa mokoallo pakeng tsa batho le lihlahisoa ha li ntse li fokotsa litšenyehelo. The isolator e hlalosoa e le kamore e hloekileng ka lebokoseng. Ts'ebetso eohle e koetsoe ka khabinete e tiisitsoeng, e hatelloa ka moea o tlhotliloeng ke li-filters tsa HEPA.
Nakong ea ts'ebetso, ha ho na opereishene ea lumelloang ho kena ntle le ka sebopeho sa li-glove. Setšoantšo se amoheloa ke chase-logeman anchaselogeman-isolator-web.jpg bakeng sa mokhoa oa ho itšehla thajana (sefate sa holimo sa HEPA ha sea bontšoa). Setšoantšo ka tlhompho ea chase-logeman anchase-logman-isolator-inside-web.jpg e fepa ka hare ho isolator e bonts'ang kou ea liatlana.
Ka mor'a tlhahiso ea tlhahiso, mochine o itšehla thajana o tla buloa, o hloekisoe, 'me o itokisetse mosebetsi o latelang. Hang ha e se e ntlafalitsoe, e itšehla thajana e tlatsoa ka ntho e thibelang likokoana-hloko, eo hangata e leng mouoane oa hydrogen peroxide (VHP), ho thibela ntho e 'ngoe le e 'ngoe e ka hare. Ho fapana le sefafatsi sa setso kapa sebolaea likokoana-hloko, VHP e kena mekoting e menyenyane ka ho fetisisa.
Ha e se e hloekisitsoe, tlhophiso efe kapa efe ea ho qetela e etsoa ka boema-kepe ba liatlana. Ka khopolo, ho lokela ho khoneha ho sebelisa motho ea ikemetseng sebakeng se sa laoleheng, joalo ka ntlo ea polokelo, ke opereishene ea apereng seaparo sa lab. Ka khopolo ho joalo.
Ebile, lik'hamphani tse ngata li kentse li-isolator ka har'a likamore tsa bohloeki tsa sehlopha sa 100. Sena se fana ka sebaka se eketsehileng sa ho hloekisa, empa bohlokoa ke ho hlahisa motho ea ikemetseng ho qoba. 3. Restricted Access Barrier System (RABS): RABS ke ho sekisetsa pakeng tsa tsamaiso e bulehileng le tsamaiso e ka thōko, RABS e na le ts'ebetso ka har'a sekoahelo se thata.
Mehato ea ts'ebetso e kena ka boema-kepe ba li-glove. Syntegon Pharma technologies Syntegon-Pharma- products_filling and Closing_FXS_3100-web.jpg RABS e bulehileng e fetela siling, e itšetlehile ka tsamaiso ea moea ea kamore le tsamaiso ea ho hloekisa. RABS e koetsoeng e na le sistimi ea eona ea ho sebetsana le moea le ho sefa.
RABS e na le melemo e mengata ea litšenyehelo ho feta batho ba itšehlang thajana ka lebaka la bonolo ba eona. Sena ke ’nete haholo-holo haeba li ka behoa likamoreng tse hloekileng tse seng li ntse li le teng ebe joale li fokotsa litšenyehelo tsa kaho. Tlhokahalo ea ho aha kamore e hloekileng e fokotsa tse ling tsa litšenyehelo ha li bapisoa le tse itšehlang thajana.
4. Lits'ebetso tse lahlehang: Lisebelisoa tsa ho sebetsana le lihlahisoa tse lahliloeng li ntse li tsebahala haholoanyane lits'ebetsong tsa aseptic. Lisebelisoa tsena li na le mokotla oa polasetiki ho nkela lekotikoti la tšepe sebaka sa setso. Mokotla o tla o phuthetsoe esale pele ka li-filters tsohle, li-tubing, likou, li-nozzles tse tlatsang, le lisebelisoa tse ling tse hlokahalang.
E koaletsoe ka mokotleng o sireletsang 'me e hloekisitsoe. Sesebelisoa sa moetsi se phethela sistimi e hloekile ebile e loketse ho sebetsa. Setšoantšo se amoheloa ke sartorioussaritus Img_OctoPlus-_4154-web.jpg Baetsi ba bang ba fana ka lisebelisoa tse tloaelehileng tsa tšebeliso e le 'ngoe, ho kenyeletsoa Sartorius (its PreVAS - pre-validated, pre-assembled, pre-sterilized - Project Syntegon), Pall Corporation (Biotech ea eona hang Tšebeliso ea Thobalano Sistimi) joalo-joalo.
Ho ea ka Marion Monstier, Sartorius Freeze-Thaw Products Manager, melemo ea mekhoa ea tšebeliso e le 'ngoe e kenyelletsa: • Lisebelisoa tse koetsoeng li fokotsa phetisetso ea lihlahisoa le ho sebetsana le tsona, ho fokotsa kotsi ea tšilafalo. • Ho fetola mekhoa ea tšebeliso e le 'ngoe pakeng tsa lihlahisoa tsa lihlahisoa ho felisa monyetla oa ho silafala ka lebaka la ho hloekisa ho sa fellang kapa ho sa lokelang. • Ha ho bapisoa le litsamaiso tse ka sebelisoang hape, litsamaiso tsena tse ling li fokotsa phetoho le nako ea ho seta.
• Ba felisa litlhoko tsa netefatso ea ho hloekisa. • Li hula hantle, kahoo li eketsa ho hlaphoheloa ha sehlahisoa.
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